Johnson suffered his in the first quarter and then walked back to the locker room, not to return. Wagner suffered his in the second quarter and needed to be carted off the field — sitting up — and he did not return.
Johnson had five carries for 16 yards and one catch for three yards before he left the game. He became the starter last month after Kerryon Johnson injured his knee against Minnesota on Oct. 20 and was placed on injured reserve.
The injury left the Lions with two healthy running backs, J.D. McKissic and Paul Perkins along with fullback Nick Bawden. Tyrell Crosby replaced Wagner at right tackle, leaving Detroit with two healthy tackles.
The Lions offense was already playing without starting quarterback Matthew Stafford for the first time since the end of the 2010 season.