Brissett suffered the injury in the second quarter when guard Quenton Nelson was pushed back into him deep in Pittsburgh territory. Brissett remained on the ground for a couple of minutes before jogging to the sideline with a noticeable limp.
Brissett, who was 4-of-5 for 59 yards prior to the injury, spent an extended amount of time in the medical tent before he put his helmet on and watched from the sideline. Though he was not officially ruled out, coach Frank Reich said it would take a “rare scenario” for Brissett to return.
Veteran Brian Hoyer, who the Colts signed following the retirement of Andrew Luck, replaced Brissett and threw two touchdowns and had an interception returned 96 yards for a touchdown by Steelers safety Minkah Fitzpatrick in the first half.